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The relationship of these allergic-like events to the polypeptide hormone or the diluent containing benzyl alcohol is not clear. Warnings and Precautions When Using HCG Injection. The precautions are as follows: General Precautions: 1. Induction of androgen secretion by HCG may induce precocious puberty in patients treated for cryptorchidism. Therapy should be discontinued if signs of precocious puberty occur. Since androgens may cause fluid retention, HCG shots should be used with caution in patients with cardiac or renal disease, epilepsy, migraine, or asthma. Carcinogenesis, Mutagenesis, Impairment of Fertility: There have been sporadic reports of testicular tumors in otherwise healthy young men receiving HCG injections for secondary infertility. A causative relationship between HCG and tumor development in these men has not been established. 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